The objective of the present investigation is to characterize physicochemical properties of MFD Formulations. The interactive mixture of powder sample was characterized in terms of compressibility characteristics, Differential Scanning Calorimetry (DSC) and Fourier Transformed Infra Red Spectroscopy (FTIR). Fast dissolving tablets were then formulated by direct compression method. The tablets were evaluated for the disintegration time, hardness, friability, tensile strength, weight variation and in vitro release studies. FTIR indicated the absence of any chemical reaction between the two species (drug and excipients) during the process of MFD tablets. DSC studies showed there is no interaction between the drug and excipients. Hausner’s ratio & Carr’s index value of interactive mixture suggested excellent flowability. The interactive mixture was found to be effective at all the concentrations tested in the fast dissolving tablet formulation. Disintegration time (DT) of less than 30 seconds was observed in case of interactive mixture. MFD can be utilized as a better option in the pharmaceutical applications.
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